First run npm install in the root PMTiles/js directory, then npm install in PMTiles/serverless/cloudflare
Edit wrangler.toml with a new name + your development and production R2 buckets.
Test in development: npm run start
Publish the worker: npm run deploy

Settings

By default, your worker will serve tiles at path NAME/0/0/0.EXT using the archive at the root of your bucket NAME.pmtiles, where EXT is one of mvt, png, jpg or webp depending on the tileset.

This behavior can be customized with optional environment variables:

PMTILES_PATH - A string like folder/{name}.pmtiles specifying the path to archives in your bucket. Default {name}.pmtiles

TILES_PATH - a string like prefix/{name}/{z}/{x}/{y}.{ext} specifying the tile path exposed by the worker. Default {name}/{z}/{x}/{y}.{ext}

ALLOWED_ORIGINS - a comma-separated list of allowed CORS origions. Default none. Examples: https://example.com,https://localhost:3000, *

Using the Workers web editor

Generate the Workers script using npm run build and copy dist/index.js to the editor.